What It Is

BPC‑157 (Body Protection Compound‑157) is a synthetic peptide derived from a naturally occurring gastric protein with healing and regenerative properties.

How It Works

Supports tissue repair and recovery by promoting angiogenesis, boosting growth factor expression, and modulating inflammation.

History & Original Use

Developed in the early 1990s at the University of Zagreb for gastrointestinal healing and tendon/ligament recovery.

Benefits

• Accelerates soft tissue healing
• Supports gut health
• Reduces inflammation
• Enhances blood flow to injured areas

Safety & Notes

Not FDA-approved. Mild side effects include injection site redness or transient nausea.

Timing & Protocol

250–500 mcg daily subcutaneous, usually 1–2 weeks for noticeable effects.

Pricing

$450 per vial / protocol customized per patient.

What It Is

A GLP-1 receptor agonist that mimics natural incretin hormones, helping regulate blood glucose and suppress appetite.

How It Works

Activates GLP-1 receptors to improve insulin secretion, slow gastric emptying, and increase satiety.

History & Original Use

FDA-approved for Type 2 diabetes (Ozempic®) and later for chronic weight management (Wegovy®).

Benefits

• Significant weight loss in trials
• Improved glycemic control
• Enhanced cardiometabolic markers
• Weekly dosing convenience

Safety & Notes

Monitor for GI side effects. Prescribed and monitored by clinicians.

Timing & Protocol

Weekly injections; results usually build over 8–16 weeks.

Pricing

$350 per month (varies by dose).

What It Is

Dual agonist peptide activating GIP and GLP-1 receptors for glucose control and weight management.

How It Works

Targets two metabolic pathways to enhance insulin secretion, satiety, and glycemic regulation.

History & Original Use

FDA-approved as Mounjaro® for Type 2 diabetes and Zepbound® for weight management.

Benefits

• High rates of clinically meaningful weight loss
• Superior glycemic control
• Cardiometabolic improvements

Safety & Notes

Requires monitoring by a clinician. GI side effects possible.

Timing & Protocol

Weekly injections with dose titration; results often 12–24 weeks.

Pricing

$500+ per month.

What It Is

Retatrutide is an investigational triple hormone receptor agonist that targets the GLP-1, GIP, and glucagon receptors in one once-weekly injectable molecule. It is designed to support enhanced metabolic regulation and significant weight loss compared with single- or dual-agonist therapies.

How It Works

By activating three hormone pathways — glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon — retatrutide not only suppresses appetite and improves insulin response like previous therapies, but also stimulates fat burning and energy expenditure through glucagon activity.

History & Original Use

Developed by Eli Lilly, retatrutide is currently under investigation in Phase 3 clinical trials for obesity, type 2 diabetes, knee osteoarthritis, sleep apnea, and other metabolic conditions. It is not yet FDA-approved and is only available through research studies.

Benefits

• Significant weight loss in clinical studies — up to ~28.7% average body weight loss over extended treatment.
• Improved metabolic markers (glucose, lipids, liver fat).
• Secondary benefits such as reduced knee pain in certain populations.
• Potential improvements in cardiometabolic risk.

Dosing & Protocol

Retatrutide is administered as a once-weekly subcutaneous injection. Research protocols typically use gradual dose escalation to minimize side effects:

• Weeks 1–4: 1–2 mg weekly
• Weeks 5–8: 2–4 mg weekly
• Weeks 9–16: 4–8 mg weekly
• Week 17 and beyond: up to 12 mg weekly

This staged titration helps balance efficacy and tolerability. It may take multiple weeks to reach steady-state levels at higher doses.

Timeline & Expected Results

• Week 1–4: Initial appetite suppression and improved satiety.
• Week 8–16: Gradual onset of weight loss and metabolic changes.
• 48–68 weeks: Significant body-weight reductions reported in clinical trials (with highest doses).

Safety & Side Effects

• Nausea, diarrhea, constipation (similar to other incretin-based therapies).
• Transient GI discomfort early in treatment.
• Hypoglycemia risk if combined with other glucose-lowering medications (clinician supervision required).
• Long-term safety and chronic use data are currently limited pending completion of late-stage trials.

Because retatrutide is still investigational and not FDA-approved, it should only be used in clinical research settings under medical supervision.

Pricing

$750+ per month.

What It Is

Synthetic analog of growth hormone-releasing hormone (GHRH) that stimulates GH production to support fat metabolism and lean mass.

How It Works

Signals pituitary gland to release endogenous GH, promoting fat breakdown and improved metabolic function.

History & Original Use

FDA-approved for reducing excess abdominal fat in HIV-associated lipodystrophy.

Benefits

• Targeted visceral fat reduction
• Supports lean body mass
• Metabolic benefits via GH modulation

Safety & Notes

Requires screening and monitoring of glucose, GH, and IGF-1.

Timing & Protocol

Daily or cyclical dosing; results visible in 8–12 weeks.

Pricing

$240 per month.

What It Is

Semorelin is a growth hormone releasing hormone (GHRH) analog that stimulates the body’s natural production of growth hormone.

How It Works

It signals the pituitary gland to increase endogenous growth hormone secretion, supporting cellular repair, metabolism, and lean muscle development.

History & Original Use

Originally approved in the 1990s for growth hormone deficiency diagnostics and therapy.

Benefits

• Improved sleep quality
• Enhanced recovery
• Lean muscle support
• Fat metabolism support

Safety & Notes

Generally well tolerated. Monitoring of IGF-1 levels recommended.

Timing & Protocol

Often taken nightly; noticeable improvements in sleep and energy within 3–6 weeks.

Pricing

$180 per vial.

What It Is

A synergistic combination of growth hormone releasing peptides designed to enhance natural GH production.

How It Works

CJC-1295 extends GH release duration, while Ipamorelin stimulates GH pulses without significantly increasing cortisol or prolactin.

History & Original Use

Developed for safer stimulation of growth hormone compared to earlier GHRP compounds.

Benefits

• Improved muscle tone
• Enhanced recovery
• Better sleep quality
• Fat loss support

Safety & Notes

Best administered in fasting state; monitor IGF-1 levels.

Timing & Protocol

Often dosed 5 nights per week; visible body composition changes in 6–12 weeks.

Pricing

$200 per protocol.

What It Is

A neuroprotective peptide originally developed in Russia for cognitive enhancement and stroke recovery support.

How It Works

Modulates BDNF (Brain-Derived Neurotrophic Factor) and neurotransmitter pathways, supporting focus, mood, and memory.

History & Original Use

Used clinically in Russia since the 1990s for neurological rehabilitation.

Benefits

• Improved cognitive clarity
• Enhanced focus
• Stress resilience

Safety & Notes

Usually administered intranasally; minimal reported side effects.

Timing & Protocol

Effects may be noticed within days; protocols often run 2–4 weeks.

Pricing

$90 per vial.

What It Is

A copper-binding peptide known for regenerative and anti-aging properties.

How It Works

Stimulates collagen production, tissue remodeling, and wound healing pathways.

History & Original Use

Discovered in the 1970s in human plasma; researched extensively in dermatology.

Benefits

• Skin tightening and rejuvenation
• Hair restoration support
• Improved wound healing

Safety & Notes

Available topical or injectable; well tolerated.

Timing & Protocol

Visible skin improvements within 4–8 weeks.

Pricing

$150 per vial.

What It Is

A mitochondrial-derived peptide supporting metabolic regulation and insulin sensitivity.

How It Works

Enhances cellular energy utilization and improves metabolic flexibility.

History & Original Use

Discovered in 2015 as part of mitochondrial signaling research.

Benefits

• Improved endurance
• Metabolic health support
• Insulin sensitivity enhancement

Safety & Notes

Research peptide; ongoing clinical investigation.

Timing & Protocol

Often used in short cycles; benefits seen within 3–4 weeks.

Pricing

$220 per vial.

What It Is

A fragment of human growth hormone targeting fat metabolism without affecting blood sugar significantly.

How It Works

Stimulates lipolysis and inhibits lipogenesis.

History & Original Use

Studied for obesity and weight management applications.

Benefits

• Supports fat loss
• Non-stimulant metabolic support

Safety & Notes

Generally well tolerated; works best combined with diet and exercise.

Timing & Protocol

Fat loss results typically visible in 6–12 weeks.

Pricing

$130 per vial.

What It Is

A synthetic version of thymosin beta-4 used for tissue repair and inflammation reduction.

How It Works

Promotes cell migration, angiogenesis, and tissue regeneration.

History & Original Use

Studied for musculoskeletal injury recovery.

Benefits

• Accelerated healing
• Reduced inflammation
• Improved flexibility

Safety & Notes

Research-based use; injection protocols vary.

Timing & Protocol

Healing support typically within 2–4 weeks.

Pricing

$140 per vial.

What It Is

An anti-inflammatory tripeptide fragment derived from alpha-MSH.

How It Works

Reduces inflammatory cytokines and supports immune balance.

History & Original Use

Researched for inflammatory bowel and autoimmune conditions.

Benefits

• Gut health support
• Immune modulation

Safety & Notes

Generally well tolerated.

Timing & Protocol

Improvements often within 2–4 weeks.

Pricing

$110 per vial.

What It Is

A synthetic tetrapeptide associated with telomere support and longevity research.

How It Works

May stimulate telomerase activity and regulate circadian rhythms.

History & Original Use

Developed in Russia for anti-aging research.

Benefits

• Sleep cycle regulation
• Longevity support

Timing & Protocol

Often cycled annually; sleep benefits within weeks.

Pricing

$160 per vial.

What It Is

An oral GLP-1 receptor agonist under development for weight management and metabolic health.

How It Works

Activates GLP-1 pathways to regulate appetite and insulin response.

History & Original Use

Newer metabolic therapy currently in clinical development.

Benefits

• Weight management support
• Improved metabolic markers

Timing & Protocol

Clinical trial dosing varies.

Pricing

Contact clinic.

What It Is

A neuropeptide involved in bonding, mood regulation, and social connection.

How It Works

Acts on central nervous system receptors influencing emotional processing and stress response.

History & Original Use

Originally used for labor induction; studied for mood and behavioral effects.

Benefits

• Enhanced emotional connection
• Mood support

Timing & Protocol

Often intranasal; effects within hours to days.

Pricing

$90 per vial.